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Heterozygous females can also sometimes have symptoms because of something called X chromosome inactivation (XCI)

2 Anxiety and Depressed Mood Women are more likely to experience manifestations of anxiety (eg, irritability, nervousness or tension, fear for no reason, and pounding heartbeat) and depressed mood (eg, sadness and crying, restless sleep, feeling lonely) during peri- and postmenopause than before menopause

Conditions such as liver cirrhosis and certain blood disorders can lead to excess bilirubin in the bile and contribute to the formation of black pigment gallstones (Tanaja 2018

Then, we introduce the various NAD types and their modes of action, with an overview of both approved NADs and those currently in clinical trials