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Blagosklonny argued that the metabolic side effects of rapamycin are a consequence of it acting as a CRM and are required to mediate its positive effects on lifespan (226)

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Ozempic is registered in South Africa for the treatment of adults with Type 2 Diabetes to reduce blood sugar levels for the treatment of adults with insufficiently controlled Type 2 Diabetes mellitus as an adjunct to diet and exercise

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