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Weeks 1-4: 2mg once weekly Weeks 5-8: 4mg once weekly Weeks 9-12: 8mg once weekly Week 13 onward: 12mg once weekly (maintenance) Total escalation time spans 12 weeks, slower than some competitors but necessary given the triple-receptor mechanism

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Reactive oxygen species and cell signaling

Laboratory measures included low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), serum creatinine (Scr), estimated glomerular filtration rate (eGFR), osteocalcin (OCN), vitamin D (VitD), and hemoglobin A1c (HbA1c), all of which were obtained from routine clinical testing