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Liu DZ, LeCluyse EL, Thakker DR

A research presents a cryo-immunochemotherapeutic approach, designated ICIE, that integrates cryosurgery with cold-responsive nanoparticles (CRNPs) co-loaded with the chemotherapeutic agent irinotecan (CPT) and PD-L1-targeting siRNA (siR) to induce robust and lasting antitumor immunity

However, in the later stages, impaired islet cell function due to prolonged hyperglycemia causes the absolute deficiency of insulin in the body 2 , and insulin remains the first-line treatment for T2DM