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Comment: The applicant acknowledged that CMS applies a high evidentiary standard for substantial clinical improvement, typically requiring robust clinical data showing improved patient outcomes such as reduced complications, fewer reoperations, faster recovery, or better functional results compared to the current standard of care

The duration for which an individual stays on semaglutide GLP-1 for weight loss is typically determined by their healthcare provider, who evaluates their health status, weight loss goals, and response to the medication

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