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Historically important, it remains used in nutritional research for its ability to strongly stimulate appetite , making it a tool for studying hypothalamic regulation of food intake

In a study using human skin tissue models (including ex vivo skin samples), Pep 14 reduced markers of cellular aging, promoted DNA repair, decreased inflammation, increased cellular renewal and collagen expression, and led to a reduction in the biological age of skin tissue by an average of 2.6 years after just five days of topical treatment

There is, however, evidence to support considering closer follow-up when initiating a GLP-1 RA, particularly if rapid improvement in glycemic control is anticipated, following a baseline dilated fundus examination performed around the time of therapy initiation

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