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Without coordinated monitoring and clinical supervision, dual therapy becomes a trial-and-error experiment rather than a evidence-backed treatment strategy

In contrast, inhibition of autophagy under such conditions resulted in cellular damage and apoptosis ( Various types of autophagy have been recognized in mammalian cells, involving i) macroautophagy, ii) microautophagy and iii) chaperone-mediated autophagy, all of which act through the lysosome-dependent pathway but differ in the machinery used to deliver autophagic cargo to the lumen of lysosomes (Ravikumar et al., 2009

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