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Furthermore, the HGF antagonist peptide Hinge blocked both Dihexa-induced spinogenesis and the associated increases in mEPSC frequency, confirming that Dihexa's procognitive effects are mediated specifically through the HGF/c-Met signaling system

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443 Unfortunately, the trial results showed that CSL112 did not significantly reduce the composite primary endpoint, challenging the longstanding hypothesis that direct enhancement of HDL function would provide clinical benefits