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Molecular Operating Environment (MOE) (9101010 Sherbrooke St

In summary, the kinetic data for the E170X mutants support a glutaredoxin-catalysed formation of GSSEtOH as well as an exclusive interaction between Glu170 and the glutathione moiety of GSSR in accordance with the glutathione-scaffold model

South Asian phenotype : the metabolic risk lands a step earlier (more visceral fat and earlier dysglycemia at a given BMI), so the target can run a notch higher