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Cultural narratives about willpower, personal responsibility, and moral failure in obesity create receptivity to messages that frame medication as cheating, addiction, or dangerous shortcuts

We often see that the effect feels clearer when you: keep track of calories avoid overeating choose smaller but more nutrient-dense portions keep a stable protein intake eat regularly rather than spontaneously Conversely, large meals, very unhealthy food or unstructured eating can drown out the medication for some users

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The increased risk for retinal complications (HR 1.76, P = 0.02) observed in subjects with retinopathy at baseline, probably due to the fast improvement of glucose control, suggests a careful use of semaglutide in these subjects [5]