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Copper peptides are active at low doses, so higher amounts do not improve outcomes

J.DrukarchB.HoozemansJ.et al (2008)

The Doa1-Cdc48 -Ufd1-Npl4 complex formed by the Ufd1-Npl4 heterodimer and Cdc48 strips ubiquitinated proteins from the mitochondrial surface via the AAA-ATPase function of Cdc48 and delivers them to the proteasome for degradation [50]