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Glucagon receptor agonism can promote energy expenditure and fatty acid oxidation, potentially enhancing weight loss effects while maintaining glucose control

The mean rate of eGFR decline was -1.4 per year in the combined tirzepatide groups and -3.6 per year in the insulin group (between-group difference 2.2 [95% CI 1.6 to 2.8]) with a greater benefit in participants with eGFR 500mg/dl the use of bile acid sequestrants is contraindicated (424)

Coskun T, Heise T, DeVries J et al (2022) Tirzepatide reduces appetite, energy intake and fat mass in people with type 2 diabetes

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