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[1] [3] Patients with severe gastrointestinal disease may require careful consideration and monitoring

These include: Blood glucose readings above your target range, especially if over 300 mg/dL Increased thirst and urination Unexplained fatigue or weakness Fruity-smelling breath Nausea or vomiting (which may indicate hyperglycemia rather than medication side effects) Seek urgent care if your blood glucose is above 300 mg/dL or above 250 mg/dL with moderate to large ketones, if you have persistent vomiting, inability to keep fluids down, confusion, or signs of dehydration

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With millions of Americans already taking GLP-1 medications and use continuing to grow, these effects on preventing and treating substance use disorders could have significant impact at the population level