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Typical TKI, sorafenib, combined with PD-1-based ICIs for advanced HCC has been proven to be safe and effective, as the median PFS of combination treatment was greatly longer than the PD-1 monotherapy, The median OS of the combination treatment group (21.63 months) was also longer than the PD-1 group (16.43 months) (Qin et al., 2022)