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Description

Mechanistically, PA disrupts intracellular iron homeostasis via ER calcium release, upregulates transferrin (TF)-mediated iron transport, and ultimately triggers ferroptotic death through iron overload ( 2.4 Induction of cell cycle arrest Cell cycle arrest, achieved by downregulating cyclins and cyclin-dependent kinases (CDKs), represents a key anti-cancer strategy

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TNF-, IL-6) and simultaneously increases anti-inflammatory signaling in injury models

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We co-overexpressed exogenous SLC7A11 and SLC3A2 in MCF-7 and ZR-75-1 cells with con-sh or ER knockdown (Fig

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histolytica and G

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