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Between each stage the resin is filtered and washed to remove byproducts, excess reagents and the terminal protecting groups, and the cycle is repeated until the final peptide is cleaved from the resin and purified using chromatography

The diagnostic process typically begins with clinical suspicion, often based on a rapidly enlarging, painful mass

During initial dose escalation, transient dyspepsia and regurgitation occurred, out of caution semaglutide treatment was continued at a lower dose of 0.5 mg weekly for the following five months, which led to a weight reduction of 8 kg

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