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Functional changes in the microbiota of low-gene-count patients primarily consist of a decrease in butyrate-producing bacteria and an increase in the ratio of Akkermansia to Ruminococcus gnavus , which lead to decreased methane production potential, decreased hydrogen production potential, enhanced mucus degradation, and increased peroxidase activity (Tims et al., 2013

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As a result, the drug conjugate showed efficacy in the treatment of glioblastoma compared with the free drug in our intracranial HIFko glioma model [93]