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Metabolism slows, muscle mass declines, hormonal shifts alter how the body stores fat, and the caloric deficit required to produce meaningful weight loss becomes more difficult to sustain through diet and exercise alone

This increases ones risk of major medical conditions such as heart disease and type 2 diabetes

This means insulin is released primarily when blood glucose levels are elevated, reducing the risk of hypoglycemia compared to some other diabetes medications

The approval allows for earlier intervention and treatment with Rybelsus in adults with type 2 diabetes, when previously it was not approved as an initial (first-line) treatment option