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Unlike FDA-approved medications that undergo rigorous testing for purity, potency, and sterility, compounded preparations lack this regulatory oversight and quality assurance

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The two Phase II failures together, in populations chosen because they might plausibly benefit, are why the program did not continue

After filtering on samples passing SomaLogic quality control (RowCheck = =TRUE) and selecting aptamers targeting human proteins, the remaining data covering 7,289 aptamers were log 10 transformed and, for each aptamer, all measurements standardized using the mean and standard deviation (s.d.) of samples obtained at baseline