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Key lipids, including ceramides, sphingomyelins, phospholipids, diacylglycerols, and triglycerides, as well as branch-chain amino acids, have been found to be dysregulated in both ME/CFS and GWS (Germain et al., 2018, 2020

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Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function

These compounds provide hydration of the skin and help form an impermeable barrier on its surface