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"Alpha-lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects." J Lipid Res

Several widely-used therapeutic drugs and drug candidates have displayed in vivo hydrolytic release of AA, alongside concomitant toxicity, whilst close structural analogues have not

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By 1997, Ng and colleagues had identified the C-terminal segment of human GH as the primary region governing fat metabolism, and created AOD 9604 by adding a tyrosine residue to the fragment to enhance its stability