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Animal studies have failed to establish a lethal dose even at concentrations thousands of times above therapeutic levels

As shown in Figure S7, key differences in the binding modes of non-cyclic ligand 7a and cyclic ligands 7b 7i were revealed through analysis of their intermolecular interaction profiles, with 7a forming numerous but low-frequency contacts - likely due to its flexible warhead - while the more rigid cyclic ligands engaged in fewer but higher-frequency interactions, indicating slightly greater binding specificity and complex stability

While the fatal infectious disease affects everyone worldwide, patients suffering from hypertension and diabetes are highly susceptible to COVID