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Cell Cycle 13 , 31833190 (2014)

Mutations in the genes coding for FA detoxifying enzymes underlie a human inherited bone marrow failure syndrome (IBMFS), even in the presence of functional DNA repair, raising the question of whether FA causes relevant cellular damage beyond genotoxicity

Works as a "scavenger" for free radicals (reactive oxygen species)

The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-B pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways (28)