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In pernicious anaemia, the immune system mistakenly attacks the gastric parietal cells that produce intrinsic factor, leading to B12 deficiency over time

Whether that multiple is justified depends entirely on whether the research question requires glucagon receptor engagement or whether the 4.3 percentage point weight loss advantage over tirzepatide (24.2% vs 20.9%) is scientifically meaningful for the study design

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Reported or plausible effects can include local irritation, redness, swelling, or discomfort at the application or injection site, as well as headache, nausea, dizziness, flushing, or fatigue