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lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy

Well have a clearer picture once these trials are completed, but for now, what we have comes from controlled study settings rather than real-world use

Third, animal and in vitro models cannot be directly generalized

If a GLP-1 prescription is deemed appropriate, medication is shipped from a licensed compounding pharmacy