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The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

2.9.3 Static light scattering (SLS) Static light scattering (SLS) is a physical chemistry technique for molecular characterization that measures the average intensity of scattered light to determine a weight-average (or absolute) molecular weight M w and size (radius of gyration, R g ) of a macromolecule, such as a polymer or a protein in solution

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Five mechanistic axes are documented: 1