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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]
The second function of the chylomicron is to transport cholesterol to the liver, although on the way the cholesterol may be taken up by tissues including the atheromatous plaque where the macrophage sits in waiting with a specific apo B48 receptor [36] as well as VLDL and scavenger receptors [35]
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