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Macrophage polarization from M1 to M2 Macrophages exist on a spectrum

Multiple cytokines and inflammatory factors participate in keloid formation, such as transforming growth factor 1(TGF-1), vascular endothelial growth factor (VEGF), interleukin (IL)-1, IL-6, and IL-8, as well as increased matrix metalloproteinases (MMP S ), which may promote fibroblast proliferation and migration, the inflammatory response, and collagen production 2,3,4

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The 10 mg group had an adjusted hazard ratio of 0.58 (95% confidence interval: 0.350.95, P = 0.03), and the 25 mg group had an adjusted hazard ratio of 0.62 (95% confidence interval: 0.380.99, P = 0.046)