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Randomisation in these trials was prospectively stratified by baseline background medication, which can be considered a strength of the current analyses

Biomark Med (2014) 8:32130.10.2217/bmm.13.158 17 FryeRESequeiraJMQuadrosEVJamesSJRossignolDA

Inflammasomes promote the maturation and secretion of the cytokine precursors pro-IL-1 and pro-IL-18 in the process of innate immune defense by inducing the activation of caspase-1, thereby triggering an inflammatory response

This creates a double-whammy: increased atherosclerotic plaque formation and elevated blood clot risk.[ref][ref] Prothrombotic effect: In addition to increasing atherosclerosis, higher Lp(a) levels also have a prothrombotic clot-forming effect during inflammation