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Afamelanotide improved prespecified light-exposure outcomes compared with placebo, and quality-of-life measurements also favoured treatment

Some people also feel concerned about appearance changes tied to losing weight

Gastrin is a neuroendocrine peptide, which acts on the cholecystokinin-2 (CCK2) receptor and is expressed in the pancreas with the rationale being that as it is involved in pancreas development, it might increase -cell mass and glycemic control [70]

They differ from GLP-1s in that they target not only the GLP-1 hormone but also the GIP (glucose-dependent insulinotropic polypeptide) hormone, which helps to lower A1C, or blood glucose levels