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Human research demonstrated that methylcobalamin supplementation in patients with inadequate B12 levels improved CD4/CD8 ratio and NK cell activity, and augmented CD3-CD16+ cells, suggesting an important role in cellular immunity.[14] In other research, among homologues studied, methylcobalamin was shown to have the strongest antibody production enhancement on an in vitro system.*[15]

Positive outcomes emerged, but further studies are needed in order to validate its clinical efficacy (Warita et al., 2019)

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The effects of intermittent fasting combined with resistance training on lean body mass: a systematic review of human studies