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Significant weight loss can often be seen within 12-16 weeks, depending on individual factors like diet and exercise

Over time, your body naturally removes these broken-down lipid cells, reducing body fat and creating a smoother, more contoured appearance

The menstrual changes are downstream effects of metabolic changes (insulin sensitivity, weight loss), not direct hormonal interference

Furthermore, urinary metabolomics has unveiled shared metabolic pathways and biomarkers between OA and other conditions, such as perturbation in glutamine metabolism, aiding in the enhanced comprehension of OA's pathological mechanisms and offering potential targets for the development of novel therapeutic strategies [91]