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Across the board, to put it bluntly, low levels of glutathione (GSH) are a marker for disease and premature death

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Histological analyses and single-cell and spatial transcriptomic profiling reveal tertiary lymphoid structures (TLSs) in lesional HS skin, characterized by organized interactions among T cells, B cells, antigen-presenting cells, and stromal elements underscoring the transition from predominantly innate to organized adaptive immune responses in Stage II disease [67, 68] (Fig