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Because it was associated with excessive urine, ancient Greek physicians called the disease 'diabetes, which they took from the Greek word for 'siphon to reflect their observation that fluids flowed through diabetic patients like a siphon (Harris)

Binding of GLP-1 or GLP-1RAs to these receptors can activate the cAMP/PKA signaling pathway, affecting key transcription factors like NF-B

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Beyond glycemic effects, GLP-1 receptor agonists slow gastric emptying, which prolongs the sensation of fullness after meals and contributes to reduced caloric intake