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These symptoms are usually most noticeable during dose escalation

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doi:10.1111/j.1574-6976.2001.tb00570.x

Emerging agents like the retatrutide peptide (a triple agonist targeting GLP-1, GIP, and Glucagon) and orforglipron peptide (an oral non-peptide GLP-1 agonist) are pushing the boundaries of what is possible in pharmacological weight loss, giving providers more options to tailor treatments to individual patient profiles