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There were some side effects, but none so severe that it raised concerns
In patients with HFpEF and obesity, both semaglutide (STEP-HFpEF) and tirzepatide (SUMMIT) significantly reduced cardiovascular death and worsening heart failure events, with concomitant improvements in quality of life and functional capacity [3,47]
Starting at a lower dose and increasing gradually, as most prescribing guidelines recommend, often reduces the intensity of these sensations
however, it has distinct features of progressive immune-mediated neuro-inflammatory evens resulting in multiple demyelinating lesions (Yamasaki and Kira 2019)
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