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GR can perform its enzymatic activity in the cytoplasm, but also in the ER and within lysosomes, mitochondria and the nucleus
#PBPK #MechanisticIVIVC #Biopharmaceutics #ModelInformedDrugDevelopment #VirtualBioequivalence #DrugDevelopment #Pharmacokinetics #GastroPlus #Simcyp #PKSim #ComputationalPharmaceutics #PharmaceuticalSciences To view or add a comment, sign in 23,126 followers
Retatrutide carries the side-effect profile of the GLP-1/GIP class nausea, vomiting, diarrhoea, constipation plus the class-level concerns we know from Mounjaro and Wegovy: gallbladder disease, pancreatitis, kidney injury from severe dehydration, and a possible thyroid C-cell tumour signal seen in rodent studies
Twenty-nine patients (14 men, 15 women, mean age 56.0 13.3 years) finished the study protocol
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