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Bile acids have demonstrated effects on stimulating GLP-1 secretion from L-cells by acting through a specific G protein-coupled receptor (TGR5) versus their other common receptor a nuclear transcription factor, FXR (115)

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Hepatology 65, 189201

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Cigna Contact Information COMMON CRITERIA FOR ZEPBOUND Prior Authorization Requirements Prior Authorization Requirements When Cigna does cover Zepbound, prior authorization is always required

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If any food reintroductions led to symptoms such as diarrhea or pain, they were excluded

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