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As with all medications, Mounjaro is associated with a range of side effects, some of which are common and generally mild to moderate in severity

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Several factors may contribute to allergic reactions to Wegovy: Active ingredient sensitivity : Hypersensitivity to semaglutide itself may occur, though anti-drug antibodies are uncommon according to clinical studies [1] Excipient reactions : The UK formulation contains inactive ingredients such as disodium phosphate dihydrate, sodium chloride, and pH adjusters, which could potentially trigger hypersensitivity in some individuals [1] Injection site factors : Local reactions at the injection site are relatively common Previous allergies : While not well-established, patients with previous allergies to other medications should exercise caution and inform their healthcare provider It is worth noting that no established association between Wegovy and chronic spontaneous urticaria (hives lasting more than six weeks without identifiable trigger) has been reported in the product information

The compound exhibits a notably long half-life of approximately 9 days (220 hours) and is metabolized primarily by cytochrome P450 3A4 to its active metabolite M1 (NS2360), which has an even longer half-life of 16 days (374 hours)