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The relationship between adipose tissue (AT) and glucose metabolism in PWS remains largely unknown, although several studies have observed indices of lower IR compared to controls (166, 183, 184)

Ongoing vomiting, severe abdominal pain, signs of dehydration, or symptoms of low blood sugar need medical review

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Similarly, inhibitory Gamma-aminobutyric acid (GABA)-ergic synapses have been implicated in ES [176] and a combination of pre- and probiotics supplemented after POS [84] was able to reverse the increased number of GABA-A2 receptors [177]