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found that repression of NRF2 antioxidant pathways served as a driver mechanism for the genetic premature aging disease Hutchinson-Gilford progeria syndrome (HGPS) [115], which is caused by constitutive progerin production, a mutant version of the nuclear protein lamin A

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Comparative efficacy and tolerability of antidepressants for acute bipolar depression in adults In the above-mentioned systematic review and network meta-analysis [7], antidepressants seemed to be an efficacious drug class but were associated with a higher risk for manic switch than antipsychotics [7]