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Genetic studies have further revealed that rare mutations in the extracellular domain of TREM2 significantly increase AD risk, to a degree comparable to carrying the high-risk apolipoprotein E (APOE) 4 allele [37]

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10.1080/16066359.2022.2074406 [DOI] [Google Scholar] Farkas DJ, Cooper ZD, Heydari LN, Hughes AC, Rawls SM, & Ward SJ (2023)