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4.6 Neuronal differentiation IMR-5/75 cells were plated in duplicates on a 6-well plate in 2 mL complete RPMI phenol red-free media (Gibco)

Contrasting with these actions of GIPR activation to reduce food intake, Gipr knockout (KO) mice, and humans with impaired function GIPR variants, are protected against obesity, also probably through a central effect, as similar observations were made in global KO mice or mice lacking Gipr in nestin, synapsin or VGAT-expressing cells 4,5,9,10,11,12