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These are a type of steroid that can cause the sebaceous gland to produce too much sebum, which can clog the pilosebaceous unit

Moreover, only 2.8 percent of the semaglutide-treated participants, versus 4.1 percent of those who received placebo, reported levels of depression at some point during treatment that required evaluation by a mental health professional

10.1128/AEM.02942-09 Pedersen MB, Gaudu P, Lechardeur D, Petit MA, Gruss A: Respiration pathways in fermentative lactic acid bacteria and uses in biotechnology