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Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis

(ii) through the deposition of drug precipitates in the submucosa or direct binding of the drug to melanin thus imparting a blue to black coloration to the oral mucosa [7]

This helps shield it from light exposure

The evidence is mixed, with some studies suggesting DSIP does not induce tolerance while user reports sometimes indicate diminishing returns with daily use