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8 In response to varied extracellular stimuli, GST gene expression has been demonstrated to be co-regulated either transcriptionally or post-transcriptionally

In addition to education on proper treatment administration, the participants of the study also received dietary and physical activity counseling aimed towards achieving 150 minutes of physical activity per week and a 500 calorie deficit per day

These are not minor improvements

Here are some clinical trials to give you an idea of the range of dosages: For schizophrenia, a clinical trial using 2400 mg/day of NAC showed increased glutathione levels and decreased glutamate levels