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Semaglutide: Mechanism Comparison | Feature | Semaglutide | Tirzepatide | Retatrutide | |---------|-------------|-------------|-------------| | Receptors | GLP-1 | GLP-1 + GIP | GLP-1 + GIP + Glucagon | | Avg

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In a study aimed to establish tirzepatde influence on lipid profile [27], at 26 weeks the three dosages of the drug decreased the levels of apoB, apoC-III levels, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles compared with both placebo and dulaglutide

Compared to healthy subjects, liraglutide AUC in patients with mild, moderate and severe hepatic impairment was on average 11%, 14% and 42% lower, respectively [see Use in Specific Populations (8.7)]