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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102

Normal hepatocytes and thyroid C-cells show little or no receptor, mitigating concerns over direct hepatic or thyroid toxicities [24, 25]

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It is usually asymptomatic and does not require treatment.11 Vertical implantation of the fifth toenail Conservative treatment consists of trimming or filing the nail to avoid friction (Fig