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Acromegaly, a condition of chronic, often decades-long, pathological GH/IGF-1 excess from a pituitary tumor, is the closest real-world model for what sustained supraphysiological IGF-1 actually does to cancer incidence over time

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Despite other correlations, the correlation of BMI with the percentage change in the weekly and monthly frequency of cramps remained significant after controlling for age and gender (Correlation coefficients: 0.257 and 0.239