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42 Substitution of Glu 21 for Ala moderately affected receptor binding (15-fold decrease), but replacement with a smaller amino acid Gly severely reduced the affinity (60-fold decrease)

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Understanding Common GLP-1 Side Effects: A Patient's Perspective When Lili Zarghami walked out of her doctors office with a free box of Mounjaro a glucagon-like peptide-1 (GLP-1) agonist from Eli Lilly she felt hopeful that the drug might help her shed extra pounds she had gained related to having polycystic ovary syndrome (PCOS)